Figure 1 .

Pedigrees of patients with hereditary pancreatitis (HP) with the mutation in the cationic trypsinogen gene. In one HP family (A; family number 1000), the R117H mutation in exon 3 was found in three affected members (1015, 1034, and 1049; see fig 2) but not in two unaffected members (1035 and 1050). In another HP family (B; family number 6000), the N21I mutation in exon 2 was identified in two affected members (6046 and 6045; see fig 3). A closed square or circle indicates a patient with pancreatitis, and a stippled symbol indicates family members suspected of having pancreatitis based on available clinical records.