Figure 2 .

DNA sequencing electropherograms of the human cationic trypsinogen gene exon 3 in the region of the mutation identified in patients with hereditary pancreatitis (HP) (A, forward sequencing; B, reverse sequencing). Heterozygosity at the second nucleotide in the frame (G/A) was shown in three affected members but not in two unaffected members in HP family 1000 (see the pedigree in fig 1A). This point mutation was predicted to result in an Arg (CGC) to His (CAC) substitution.