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DNA sequencing electropherograms of the human cationic trypsinogen gene exon 2 in the region of the mutation identified in patients with hereditary pancreatitis (HP) (A, forward sequencing; B, reverse sequencing). Heterozygosity at the second nucleotide in the frame (A/T) was shown in two affected members in HP family 6000 (see the pedigree in fig 1B). This point mutation was predicted to result in an Asn (AAC) to Ile (ATC) substitution.
