Figure 3  .

Vasoactive intestinal peptide (VIP) and somatostatin receptors in a surgically resected sample of hepatocellular carcinoma (HCC) containing tumour and liver tissue. (A) Haematoxylin and eosin stained section showing HCC (T) and adjacent liver (L). (B) Autoradiogram showing total binding of ¹²⁵I-VIP in the section shown in A. (C) Autoradiogram showing non-specific binding of ¹²⁵I-VIP. (D) Autoradiogram showing total binding of ¹²⁵I-[Tyr³]-octreotide (corresponding to a section different but consecutive to that in A). (E) Autoradiogram showing non-specific binding of ¹²⁵I-[Tyr³]-octreotide. VIP receptors were identified in liver tissue but not in HCC (B); somatostatin receptors were identified in HCC but not in liver (D). Liver had high non-specific binding for ¹²⁵I-[Tyr³]-octreotide (seen in E). Bar = 1 mm.