Figure 7  .

Effect of ODQ (1H-1,2,4-oxadiazole-4,3-a-quinoxaline-1-one) on the action of 1 mM S-nitroso-N-acetyl- penicillamine (SNAP, shaded bars) on apoptosis (Hoechst 33258 staining), cyclic GMP content, and on detachment of cells from the culture plate. The attached cells in panels A and C had been treated with 25 µM C₆-ceramide to induce apoptosis. Results in B are for detached cells. Data in A, B, C, and D are mean (SEM) of five, four, three, and three cell preparations, respectively, and were subjected to analysis of variance followed by a Newman-Keuls multiple comparison test. *p<0.05, **p<0.01,***p<0.001 for the effect of SNAP; †p<0.05 for the effect of ODQ in the presence of SNAP.