Figure 1  .

Application of C difficile toxin A by pressure microejection depolarised and enhanced the excitability of neurones in the submucous plexus. The top and bottom records are continuous. The neurone failed to discharge action potentials in response to intraneuronal injection of rectangular depolarising current pulses before application of the toxin. After application, slowly activating depolarisation of the membrane potential occurred. The depolarisation was accompanied by enhanced excitability as reflected by repetitive action potential discharge evoked by intraneuronal current injection and spontaneous spike discharge. The neurone had uniaxonal morphology.