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Intracellular cascades of the gp130 receptor. After interleukin 6 (IL-6) binding to gp80, two gp130 molecules homodimerise and activate JAK kinases which in turn phosphorylate the intracellular tyrosines of the gp130 receptor. Via the different phosphotyrosines, STAT1/3 and Ras dependent pathways are activated in the cell.
