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. 2000 Oct 17;97(22):11978–11983. doi: 10.1073/pnas.210392297

Figure 1.

Figure 1

A stepwise mechanism of HIV RT RNase H. Pattern lines represent DNA, whereas the solid lines represent RNA. The rectangle represents RT with the indents corresponding to the polymerase (P) and the RNase H (H) active sites. The numbered arrows indicate the length of cleavage products. The same symbols are used in the following figures. The schematic shows a linear order of cleavage events: primary, secondary, next primary, then next secondary.