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Immunohistochemistry of cyclooxygenase (COX)-2 enzyme in ulcerated human gastric mucosa. Immunoreactivity is seen on (A) macrophages in lamina propria proximal to the ulcer rim, (B) myofibroblasts at the ulcer base or granulation tissue, and (C) vascular endothelial cells in the submucosa next to the ulcer.
