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Multipoint linkage analyses of chromosome 12 in 95 multiplex families with Crohn's disease (CD) using the Genehunter package. (A) Information content; (B) multipoint non-parametric linkage (NPL) statistics. The region implicated by Satsangi et al9 containing the inflammatory bowel disease (IBD) susceptibility locus is indicated by a shaded box. (C) Exclusion map calculated for a hypothetical locus with a relative risk λs=2. The exclusion threshold of LOD score (−2) is indicated.
