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Time course of the inhibitory effect of chagasic IgG, 5 × 10−7 M (▴) and antipeptide autoantibody, 1 × 10−8 M (•) on isolated normal rat atrial spontaneous frequency. The neutralising action of 5 × 10−7 M peptide on chagasic IgG effect (▪) is also shown. Zero refers to the basal values of atrial rate (beats/min) before additions of different reagents. Values are means, error bars = SEM, of 12 chagasic IgGs and the corresponding IgG antipeptides.
