Figure 2  .

Signalling pathways associated with myocardial hypertrophy. A simplified overview of our current understanding of the intracellular signalling pathways leading to myocardial hypertrophy. Although the molecular events coupling membrane receptors to nuclear events have not been fully documented, three principal arms (with interpathway crosstalk) are described, each converging onto a common pathway (mitogen activated protein kinase cascade) which ultimately leads to the nucleus. Considerable work remains to be done to fully characterise the pathways before any potential therapeutic targets can be identified.