Figure 5.

Gene transfer of SLP-76 into SLP-76-deficient bone marrow restores hemostasis. Bone marrow harvested from SLP-76-deficient mice was infected with a retrovirus encoding GFP alone or GFP plus SLP-76 (SLP-76/GFP) and then administered i.v. into lethally irradiated Rag2^−/− hosts. Mice were killed and tissues were harvested for study 6 wk later. Axillary lymph nodes were removed and photographed. Control lymph nodes from C57/BL6 and Rag2^−/− mice are also shown. Similar results were seen in three independent experiments.