Figure 1  .

Effect of high loading dose of clopidogrel on ADP induced platelet aggregation. Patients were randomised into three treatment arms: ticlopidine 2 × 500 mg plus 2 × 250 mg daily thereafter (n = 10); clopidogrel 300 mg loading dose plus 1 × 75 mg daily (n = 10); and clopidogrel 600 mg loading dose plus 2 × 75 mg daily thereafter (n = 10). All patients received aspirin 2 × 100 mg/day concomitantly. Platelet aggregation was studied after stimulation with ADP (20 µmol/l) by light transmittance aggregometry in citrated platelet rich plasma. *Significant difference (p < 0.05) compared to starting concentrations.