Table 1.

The numbers of yeast and worm proteins observed and predicted to target mitochondria

Organism	Experimental			Estimated total number of mitochondrial proteins*
	Prokaryote-derived† (% of total)	Eukaryote-derived‡ (% of total)	Organism-specific§ (% of total)	Prokaryote-derived†	Eukaryote-derived‡	Organism-specific§	Total (% of genome)
Yeast	223  (58%)	75  (20%)	86  (22%)	365  ± 28	126  ± 10	138  ± 1	630  ± 49  (10%)
Worm	89  (61%)	55  (38%)	1  (1%)	405  ± 85	252  ± 53	7  ± 1	663  ± 139  (4%)

Predicted mitochondrial proteins are proteins from the complete genomes of yeast or worm assigned to mitochondria by using the algorithm of Fig. 2 with a training set consisting of all experimentally localized yeast proteins. 

^*Values shown are averages of predictions for each of the 60 values of coverage and accuracy plotted in Fig. 3, scaled up as described in the text. 

^†Proteins with ≥1 homolog detected in the prokaryotic genomes listed in Fig. 1A. 

^‡Proteins with no homologs in the prokaryotic genomes in Fig. 1A, but with eukaryotic homologs. 

^§Proteins with no homologs detected in genomes listed in Fig. 1A.