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. 1995 Feb;63(2):720–723. doi: 10.1128/iai.63.2.720-723.1995

Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro.

Y Zhan 1, C Cheers 1
PMCID: PMC173059  PMID: 7822049

Abstract

Marked differences in the abilities of living and heat-killed Brucella abortus and Listeria monocytogenes organisms to induce production of tumor necrosis factor alpha by in vitro-cultured macrophages were observed. Interleukin-1 and interleukin-6 appeared to be under different control. The results are discussed in relation to the induction of gamma interferon-producing Th1 cells and acquired cellular resistance to infection by living vaccines but not killed vaccines.

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Selected References

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