Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 2000 Jun;53(6):419–423. doi: 10.1136/jcp.53.6.419

Neonatal thrombosis

E Chalmers 1
PMCID: PMC1731217  PMID: 10911798

Full Text

The Full Text of this article is available as a PDF (104.2 KB).

graphic file with name 99357.f1.jpg

Open in a new tab

Figure 1 An acute ischaemic limb in a noenate secondary to a catheter related thrombosis.

graphic file with name 99357.f2.jpg

Open in a new tab

Figure 2 Digital gangrene in a neonate with protein C deficiency.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrew M., David M., deVeber G., Brooker L. A. Arterial thromboembolic complications in paediatric patients. Thromb Haemost. 1997 Jul;78(1):715–725. [PubMed] [Google Scholar]
  2. Andrew M., Michelson A. D., Bovill E., Leaker M., Massicotte M. P. Guidelines for antithrombotic therapy in pediatric patients. J Pediatr. 1998 Apr;132(4):575–588. doi: 10.1016/s0022-3476(98)70343-9. [DOI] [PubMed] [Google Scholar]
  3. Andrew M., Paes B., Johnston M. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol. 1990 Spring;12(1):95–104. doi: 10.1097/00043426-199021000-00019. [DOI] [PubMed] [Google Scholar]
  4. Andrew M., Paes B., Milner R., Johnston M., Mitchell L., Tollefsen D. M., Powers P. Development of the human coagulation system in the full-term infant. Blood. 1987 Jul;70(1):165–172. [PubMed] [Google Scholar]
  5. Andrew M., Vegh P., Johnston M., Bowker J., Ofosu F., Mitchell L. Maturation of the hemostatic system during childhood. Blood. 1992 Oct 15;80(8):1998–2005. [PubMed] [Google Scholar]
  6. Aschka I., Aumann V., Bergmann F., Budde U., Eberl W., Eckhof-Donovan S., Krey S., Nowak-Göttl U., Schobess R., Sutor A. H. Prevalence of factor V Leiden in children with thrombo-embolism. Eur J Pediatr. 1996 Dec;155(12):1009–1014. doi: 10.1007/BF02532520. [DOI] [PubMed] [Google Scholar]
  7. Chalmers E. A., Gibson B. E. Thrombolytic therapy in the management of paediatric thromboembolic disease. Br J Haematol. 1999 Jan;104(1):14–21. doi: 10.1111/j.1365-2141.1999.01053.x. [DOI] [PubMed] [Google Scholar]
  8. Chowdhury V., Lane D. A., Mille B., Auberger K., Gandenberger-Bachem S., Pabinger I., Olds R. J., Thein S. L. Homozygous antithrombin deficiency: report of two new cases (99 Leu to Phe) associated with arterial and venous thrombosis. Thromb Haemost. 1994 Aug;72(2):198–202. [PubMed] [Google Scholar]
  9. David M., Andrew M. Venous thromboembolic complications in children. J Pediatr. 1993 Sep;123(3):337–346. doi: 10.1016/s0022-3476(05)81730-5. [DOI] [PubMed] [Google Scholar]
  10. Dreyfus M., Masterson M., David M., Rivard G. E., Müller F. M., Kreuz W., Beeg T., Minford A., Allgrove J., Cohen J. D. Replacement therapy with a monoclonal antibody purified protein C concentrate in newborns with severe congenital protein C deficiency. Semin Thromb Hemost. 1995;21(4):371–381. doi: 10.1055/s-2007-1000658. [DOI] [PubMed] [Google Scholar]
  11. Hagstrom J. N., Walter J., Bluebond-Langner R., Amatniek J. C., Manno C. S., High K. A. Prevalence of the factor V leiden mutation in children and neonates with thromboembolic disease. J Pediatr. 1998 Dec;133(6):777–781. doi: 10.1016/s0022-3476(98)70150-7. [DOI] [PubMed] [Google Scholar]
  12. Kodish E., Potter C., Kirschbaum N. E., Foster P. A. Activated protein C resistance in a neonate with venous thrombosis. J Pediatr. 1995 Oct;127(4):645–648. doi: 10.1016/s0022-3476(95)70131-1. [DOI] [PubMed] [Google Scholar]
  13. Leaker M., Massicotte M. P., Brooker L. A., Andrew M. Thrombolytic therapy in pediatric patients: a comprehensive review of the literature. Thromb Haemost. 1996 Aug;76(2):132–134. [PubMed] [Google Scholar]
  14. Mahasandana C., Veerakul G., Tanphaichitr V. S., Suvatte V., Opartkiattikul N., Hathaway W. E. Homozygous protein S deficiency: 7-year follow-up. Thromb Haemost. 1996 Dec;76(6):1122–1122. [PubMed] [Google Scholar]
  15. Manco-Johnson M. J., Abshire T. C., Jacobson L. J., Marlar R. A. Severe neonatal protein C deficiency: prevalence and thrombotic risk. J Pediatr. 1991 Nov;119(5):793–798. doi: 10.1016/s0022-3476(05)80305-1. [DOI] [PubMed] [Google Scholar]
  16. Marlar R. A., Neumann A. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies. Semin Thromb Hemost. 1990 Oct;16(4):299–309. doi: 10.1055/s-2007-1002683. [DOI] [PubMed] [Google Scholar]
  17. Massicotte P., Adams M., Marzinotto V., Brooker L. A., Andrew M. Low-molecular-weight heparin in pediatric patients with thrombotic disease: a dose finding study. J Pediatr. 1996 Mar;128(3):313–318. doi: 10.1016/s0022-3476(96)70273-1. [DOI] [PubMed] [Google Scholar]
  18. Millar D. S., Allgrove J., Rodeck C., Kakkar V. V., Cooper D. N. A homozygous deletion/insertion mutation in the protein C (PROC) gene causing neonatal Purpura fulminans: prenatal diagnosis in an at-risk pregnancy. Blood Coagul Fibrinolysis. 1994 Aug;5(4):647–649. [PubMed] [Google Scholar]
  19. Nowak-Göttl U., Dübbers A., Kececioglu D., Koch H. G., Kotthoff S., Runde J., Vielhaber H. Factor V Leiden, protein C, and lipoprotein (a) in catheter-related thrombosis in childhood: a prospective study. J Pediatr. 1997 Oct;131(4):608–612. doi: 10.1016/s0022-3476(97)70071-4. [DOI] [PubMed] [Google Scholar]
  20. Nowak-Göttl U., von Kries R., Göbel U. Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child Fetal Neonatal Ed. 1997 May;76(3):F163–F167. doi: 10.1136/fn.76.3.f163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. O'Neill J. A., Jr, Neblett W. W., 3rd, Born M. L. Management of major thromboembolic complications of umbilical artery catheters. J Pediatr Surg. 1981 Dec;16(6):972–978. doi: 10.1016/s0022-3468(81)80858-5. [DOI] [PubMed] [Google Scholar]
  22. Schmidt B., Andrew M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics. 1995 Nov;96(5 Pt 1):939–943. [PubMed] [Google Scholar]
  23. Schmidt B., Buchanan M. R., Ofosu F., Brooker L., Hirsh J., Andrew M. Antithrombotic properties of heparin in a neonatal piglet model of thrombin-induced thrombosis. Thromb Haemost. 1988 Oct 31;60(2):289–292. [PubMed] [Google Scholar]
  24. Sánchez J., Velasco F., Alvarez R., Román J., Torres A. Aortic thrombosis in a neonate with hereditary antithrombin III deficiency: successful outcome with thrombolytic and replacement treatment. Acta Paediatr. 1996 Feb;85(2):245–247. doi: 10.1111/j.1651-2227.1996.tb14003.x. [DOI] [PubMed] [Google Scholar]
  25. Tabbutt S., Griswold W. R., Ogino M. T., Mendoza A. E., Allen J. B., Reznik V. M. Multiple thromboses in a premature infant associated with maternal phospholipid antibody syndrome. J Perinatol. 1994 Jan-Feb;14(1):66–70. [PubMed] [Google Scholar]
  26. Zenz W., Arlt F., Sodia S., Berghold A. Intracerebral hemorrhage during fibrinolytic therapy in children: a review of the literature of the last thirty years. Semin Thromb Hemost. 1997;23(3):321–332. doi: 10.1055/s-2007-996104. [DOI] [PubMed] [Google Scholar]
  27. Zenz W., Bodó Z., Plotho J., Streif W., Male C., Bernert G., Rauter L., Ebetsberger G., Kaltenbrunner K., Kurnik P. Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke. Thromb Haemost. 1998 Nov;80(5):763–766. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES