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Diabetogenic effect of anti-CTLA-4 mAb treatment in the naive BDC2.5 T cell transfer system
| Treatment | Insulitis at d7 | Diabetes |
|---|---|---|
| Ctl mAb | Mild, nonaggressive | 3 /18 |
| α-CTLA-4 mAb | Aggressive | 7 /8 |
Adult Cαo/o/NOD hosts received 1–2 × 107 erythrocyte-depleted splenocytes from 10- to 12-day-old BDC2.5/NOD donors. The indicated mAbs were routinely given at the time of transfer and 3 days later.
