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Comparison of insulitis development in animals administered α-CTLA-4 versus control mAb
| Treatment | Assessment of insulitis at day | No. of mice | % insulitis in individual mice |
|---|---|---|---|
| α-CTLA-4 | 5 | 6 | 9, 0, 12*, 3, 9*, 62* |
| Control | 5 | 7 | 0, 5, 9, 0, 0, 7, 2 |
| α-CTLA-4 | 7 | 2 | 94*, 79* |
| Control | 7 | 2 | 50, 5 |
Aggressive insulitis.
