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. 2000 Oct 17;97(22):12227–12232. doi: 10.1073/pnas.220399597

Figure 5.

Figure 5

PEX inhibits human melanoma (M21L) growth in nude mice. (A) Two representative examples of nude mice 20 days after tumor implantation injected with PBS (Left) or with PEX-LV (Right). (B) Analysis of tumor volume starting 5 days after tumor implantation. Five days after implanting the tumors, PBS (black), Lac-LV (blue), or PEX-LV (red) was injected around the tumor, n = 7, for each group. (C) Analysis of PEX expression and vascularization in tumors. Staining with polyclonal Abs against FLAG-tag (i) and CD31(PECAM-1) (ii) in a section through a tumor treated with PEX-LV. (iii) Merger of i and ii. (iv) Representative histological sections of a PBS-treated tumor. The arrows indicate the border of the tumor. (D and E) Effect of PEX on tumor weight (D) and tumor-induced angiogenesis (E).