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. 2000 Oct 10;97(22):12233–12238. doi: 10.1073/pnas.210253497

Figure 6.

Figure 6

Suppression of BCR/ABL-induced murine leukemia by ABD/SHP1c. SCID mice were reconstituted by using bone marrow cells infected with retrovirus constructs encoding GFP + p210 BCR/ABL (▴, nine mice), ABD/SHP1c + p210 BCR/ABL (●, nine mice), or ABD/SHP1c + GFP (⧫, three mice). All deaths were diagnosed as leukemias based on gross, microscopic, and FACS analysis. Survival data are presented as a Kaplan–Meyer plot. (Inset) p210 BCR/ABL expression from infected fibroblast cells demonstrating that equivalent virus titers were used for bone marrow infection (lane 1, mock; lane 2, GFP + p210; lane 3, ABD/SHP1c + p210).