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. 2000 Oct 10;97(22):12233–12238. doi: 10.1073/pnas.210253497

Figure 7.

Figure 7

Expression of ABD/SHP1c reverts the transformed phenotype of a chronic myelogenous leukemia line. (A) K562 cells were infected with the indicated virus (59% infection efficiency for ABD/SHP1c). Soft agar colonies that expressed GFP were counted and mean (duplicate) values were reported as a percentage (vector = 478 ± 25 colonies, all GFP positive; ABD/SHP1c = 228 ± 14 colonies, none GFP positive). (B) Globin expression was examined by benzidine staining in K562 cells infected with the indicated virus construct (95% infection efficiency for ABD/SHP1c). Vector only, 3% of cells stained positive (arrows). ABD/SHP1c, 73% of cells stained positive.