Table 1.

Transformation blockade by ABD/SHP1c requires both escort and phosphatase functions

Infection constructs	No. of soft agar colonies/104 cells	Colony size
Mock	0
BCR/ABL
+ GFP	343  ± 73 (n = 8)	Med-large
+ ABD/SHP1c	37  ± 9 (n = 5)	Small
+ ABD/SHP1cCS	303  ± 76 (n = 5)	Med-large
+ ABD™/SHP1c	372  ± 87 (n = 6)	Med-large

Rat1 cells were infected with retrovirus constructs expressing p210 BCR/ABL and the indicated gene then was cultured in soft agar. Colony number and average size were determined after 3 weeks (small, 0.3–0.5 mm; med, 0.5–1 mm; large, >1 mm).