Table 2.
Type | Total no. of tumors with p53 mutations | Tumors with a single p53
mutation
|
Tumors with multiple p53
mutations
|
Frequency¶ of tumors with
silent p53 mutations, %
|
|||
---|---|---|---|---|---|---|---|
No. of nonsilent mutations | No. of silent mutations | No. of nonsilent mutations | No. of silent mutations | Singlets | Total | ||
Lung (63% vs. 31%)* | |||||||
Smokers total | 328 | 306 | 8 | 26 | 4 | 1.54 | 2.30 |
Nonsmokers total | 73 | 67 | 4 | 4 | 0 | 1.70 | 1.70 |
Smokers only† | 278 | 263 | 8 | 15 | 1 | 1.81 | 2.04 |
Nonsmokers only† | 68 | 63 | 4 | 2 | 0 | 1.82 | 1.82 |
Oral cavity + esophagus (57% vs. 33%)* | |||||||
Smokers total‡ | 316 | 287 | 6 | 43 | 5 | 1.08 | 1.98 |
Nonsmokers total | 84 | 78 | 3 | 6 | 0 | 1.18 | 1.18 |
Smokers only‡§ | 170 | 154 | 6 | 20 | 1 | 2.01 | 2.35 |
Nonsmokers only§ | 46 | 41 | 3 | 4 | 0 | 2.15 | 2.15 |
Shown in parentheses are the percentages of tumors with p53 mutations in smokers and nonsmokers, respectively.
† Cases of radon, asbestos, and mustard gas exposure excluded.
‡Include the cases of snuffing and chewing tobacco.
§Cases of drinking alcohol and hot beverages excluded.
¶ For each group, the frequency was calculated as: F = [(no. of tumors with p53 mutations of interest)/(total no. of tumors in the group)] × 100%. The latter was estimated as [(no. of tumors with p53 mutations in the group)/% of these tumors] × 100%. For example, the overall frequency of lung tumors with silent p53 mutations (single ones + those in p53 multiplets) in the group “smokers total,” F = [(8 + 4)/(328 × 100%/63%] × 100%) = (12/328) × 63% = 2.3%.