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Generation of rgs2-deficient mice. (A) rgs2 targeting vector. (B) Southern blot (see 3′ flanking probe in A) from rgs2 mutant ES cell clones. Wild-type (WT) and mutant (KO) bands are shown. (C) Genotyping of rgs2 mice. WT and KO PCR primers are shown in A (arrows). Loss of the wild-type rgs2 allele was confirmed by genomic Southern blot. (D) Northern blot analysis of brain mRNA from rgs2 WT (+/+), heterozygous (+/−), and KO (−/−) mice (full-length rgs2 cDNA probe).
