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. 2000 Oct 10;97(22):12300–12305. doi: 10.1073/pnas.210396697

Figure 1.

Figure 1

Transformation of GABAergic BAS-CA1 synapses by RyR activation. (a) Stimulation of local GABAergic neurons elicited a monophasic IPSC recorded in a hippocampal CA1 pyramidal cell under whole-cell patch voltage clamp. BIC (1 μM, 30 min) eliminates (b) whereas kynurenate (KYN; 500 μM, 20 min) does not alter (c) the evoked IPSPs. (d—f) The relationship between the evoked BAS-CA1 PSP at different membrane potentials can be described with a straight line, determined by the least-sum squares criterion, and is not altered by kynurenate.