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Seizure grade and AD duration in hippocampal kindling differ between GFRα2 +/+ and −/− mice. Knock-out mice displayed marked retardation of kindling development as expressed by lower mean seizure grade (A) and shorter AD duration (B) (P < 0.05, repeated measures ANOVA; n = 10 for GFRα2 +/+ and n = 7 for −/− mice). Each value represents the mean of five consecutive stimulations ±SEM.
