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. 2000 Oct 24;97(22):12312–12317. doi: 10.1073/pnas.97.22.12312

Figure 2.

Figure 2

GFRα2 −/− mice require more stimulations to reach higher seizure grades, and the persistence of hyperexcitability is less pronounced. (A) The number of stimulations to reach different seizure grades. (B and C) Mean seizure grade and AD duration, respectively, in response to the first and last five stimulations during kindling, and after the five test stimulations. The number of stimulations to exhibit forelimb clonus (grade 3), generalized seizures (grades 4 and 5), and the fully kindled state (third grade 5) was significantly increased in GFRα2 −/− mice (A). The mean seizure grade (B) and AD duration (C) induced by test stimulations were significantly lower and shorter, respectively, in GFRα2 −/− mice. Mean ± SEM. *, P < 0.05, Student's unpaired t test (A) and one-way ANOVA followed by Bonferroni/Dunn post hoc test (B and C) (n = 10 for GFRα2 +/+ and n = 7 for −/− mice).