Table 1.
Seizure characteristics during development of hippocampal kindling in GFRα2 +/+ and −/− mice
| Animals | Seizure threshold, μA | AD duration (s) at different
seizure grades
|
Behavioral convulsions,
s
|
Secondary AD duration, s
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | Latency | Duration | Kindling stim. | Test stim. | ||
| GFRα2 +/+ (n = 10) | 30 ± 2 | 25 ± 2 | 26 ± 1 | 33 ± 4 | 34 ± 3 | 36 ± 3 | 16 ± 1 | 17 ± 1 | 48 ± 6 | 77 ± 20 |
| GFRα2 −/− (n = 7) | 27 ± 2 | 22 ± 2 | 22 ± 1 | 23 ± 1 | 28 ± 2 | 34 ± 2 | 16 ± 2 | 14 ± 1 | 24 ± 8* | 41 ± 14 |
Values are means ± SEM. *, P < 0.05, Student's unpaired t test. The AD duration at different seizure grades is significantly shorter in GFRα2 −/− as compared with +/+ mice (P < 0.05, repeated measures ANOVA). n, number of animals.