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Effects of single aspartate substitutions in PKC sites on sensitivity of the Cav1.2 channel to PKC. (A) Peak Ba2+ currents for T31D elicited by a depolarizing step from −80 mV to +10 mV every 15 s. OAG (20 μM) was applied for the time indicated by the horizontal bar. (B) The average inhibition by OAG is shown for T27D (n = 4) and T31D (n = 5). For comparison, the effect of PMA on wild-type Cav1.2 (WT) is also plotted.
