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Ambulatory activity of Mc4r-null mice. Data are presented as meters traveled. The locomotion during the first hour represents activity in a novel environment; locomotion during 12-h light and dark cycles was recorded 24 h later. (A) Ambulatory activity of 4- to 8-wk-old WT (n = 10) and Mc4r-null (n = 11) females. (B) Ambulatory activity of 4- to 8-wk-old WT (n = 13) and Mc4r-null (n = 14) males. *, Significant difference between WT and Mc4r-null (P < 0.05).
