Partial alignment of the amino acid sequence of selected ZIP family
members. Functional transport data are available for the 11 ZIP family
members shown here; to date, other members of this family have not been
functionally characterized. Identical amino acids and conservative
substitutions are shaded in gray; the residues targeted for mutation
are shown in black. (A) Alignment of residues
corresponding to IRT1 residues 77–149. (B) Alignment of
residues corresponding to IRT1 residues 180–309. GenBank accession
numbers are as follows: IRT1, U27590; LeIRT1, AF136579; LeIRT2,
AF136580; RIT1, AF065444; ZIP1, AF033535; ZIP2, AF033536; ZIP3,
ZF033537; ZRT1, P32804; ZRT2, Z73302; ZNT1, AF133267; hZIP2,
AF186081.