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. 2004 Sep;80(947):516–526. doi: 10.1136/pgmj.2003.008664

Probiotics and human health: a clinical perspective

H Gill 1, F Guarner 1
PMCID: PMC1743098  PMID: 15356352

Abstract

There is unequivocal evidence that administration of probiotics could be effective in the treatment of acute infectious diarrhoea in children and the prevention of antibiotic associated diarrhoea and nosocomial/community acquired diarrhoea. Encouraging evidence is also emerging for the effectiveness of probiotics in the prevention and management of pouchitis and paediatric atopic diseases, and the prevention of postoperative infections. There is also strong evidence that certain probiotic strains are able to enhance immune function, especially in subjects with less than adequate immune function such as the elderly. Efficacy of probiotics in the prevention of traveller's diarrhoea, sepsis associated with severe acute pancreatitis, and cancers, the management of ulcerative colitis, and lowering of blood cholesterol remains unproven. In addition to firm evidence of efficacy (for a range of conditions), major gaps exist in our knowledge regarding the mechanisms by which probiotics modulate various physiological functions and the optimum dose, frequency, and duration of treatment for different probiotic strains.

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Selected References

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  1. Agerholm-Larsen L., Bell M. L., Grunwald G. K., Astrup A. The effect of a probiotic milk product on plasma cholesterol: a meta-analysis of short-term intervention studies. Eur J Clin Nutr. 2000 Nov;54(11):856–860. doi: 10.1038/sj.ejcn.1601104. [DOI] [PubMed] [Google Scholar]
  2. Aso Y., Akaza H., Kotake T., Tsukamoto T., Imai K., Naito S. Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP Study Group. Eur Urol. 1995;27(2):104–109. doi: 10.1159/000475138. [DOI] [PubMed] [Google Scholar]
  3. Aso Y., Akazan H. Prophylactic effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer. BLP Study Group. Urol Int. 1992;49(3):125–129. doi: 10.1159/000282409. [DOI] [PubMed] [Google Scholar]
  4. Björkstén B., Naaber P., Sepp E., Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999 Mar;29(3):342–346. doi: 10.1046/j.1365-2222.1999.00560.x. [DOI] [PubMed] [Google Scholar]
  5. Borruel N., Carol M., Casellas F., Antolín M., de Lara F., Espín E., Naval J., Guarner F., Malagelada J. R. Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria. Gut. 2002 Nov;51(5):659–664. doi: 10.1136/gut.51.5.659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Borruel Natalia, Casellas Francesc, Antolín María, Llopis Marta, Carol Monica, Espíin Eloy, Naval Javier, Guarner Francisco, Malagelada Juan R. Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa. Am J Gastroenterol. 2003 Apr;98(4):865–870. doi: 10.1111/j.1572-0241.2003.07384.x. [DOI] [PubMed] [Google Scholar]
  7. Bullen C. L., Tearle P. V., Stewart M. G. The effect of "humanised" milks and supplemented breast feeding on the faecal flora of infants. J Med Microbiol. 1977 Nov;10(4):403–413. doi: 10.1099/00222615-10-4-403. [DOI] [PubMed] [Google Scholar]
  8. Casellas F., Borruel N., Papo M., Guarner F., Antolín M., Videla S., Malagelada J. R. Antiinflammatory effects of enterically coated amoxicillin-clavulanic acid in active ulcerative colitis. Inflamm Bowel Dis. 1998 Feb;4(1):1–5. doi: 10.1097/00054725-199802000-00001. [DOI] [PubMed] [Google Scholar]
  9. Cremonini F., Di Caro S., Nista E. C., Bartolozzi F., Capelli G., Gasbarrini G., Gasbarrini A. Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2002 Aug;16(8):1461–1467. doi: 10.1046/j.1365-2036.2002.01318.x. [DOI] [PubMed] [Google Scholar]
  10. D'Haens G. R., Geboes K., Peeters M., Baert F., Penninckx F., Rutgeerts P. Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology. 1998 Feb;114(2):262–267. doi: 10.1016/s0016-5085(98)70476-7. [DOI] [PubMed] [Google Scholar]
  11. D'Souza Aloysius L., Rajkumar Chakravarthi, Cooke Jonathan, Bulpitt Christopher J. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 2002 Jun 8;324(7350):1361–1361. doi: 10.1136/bmj.324.7350.1361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Donnet-Hughes A., Rochat F., Serrant P., Aeschlimann J. M., Schiffrin E. J. Modulation of nonspecific mechanisms of defense by lactic acid bacteria: effective dose. J Dairy Sci. 1999 May;82(5):863–869. doi: 10.3168/jds.S0022-0302(99)75304-X. [DOI] [PubMed] [Google Scholar]
  13. Fang H., Elina T., Heikki A., Seppo S. Modulation of humoral immune response through probiotic intake. FEMS Immunol Med Microbiol. 2000 Sep;29(1):47–52. doi: 10.1111/j.1574-695X.2000.tb01504.x. [DOI] [PubMed] [Google Scholar]
  14. Fukushima Y., Kawata Y., Hara H., Terada A., Mitsuoka T. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol. 1998 Jun 30;42(1-2):39–44. doi: 10.1016/s0168-1605(98)00056-7. [DOI] [PubMed] [Google Scholar]
  15. Gill H. S., Cross M. L., Rutherfurd K. J., Gopal P. K. Dietary probiotic supplementation to enhance cellular immunity in the elderly. Br J Biomed Sci. 2001;58(2):94–96. [PubMed] [Google Scholar]
  16. Gill H. S., Rutherfurd K. J., Cross M. L. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J Clin Immunol. 2001 Jul;21(4):264–271. doi: 10.1023/a:1010979225018. [DOI] [PubMed] [Google Scholar]
  17. Gill H. S., Rutherfurd K. J., Cross M. L., Gopal P. K. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr. 2001 Dec;74(6):833–839. doi: 10.1093/ajcn/74.6.833. [DOI] [PubMed] [Google Scholar]
  18. Gill Harsharnjit S. Probiotics to enhance anti-infective defences in the gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2003 Oct;17(5):755–773. doi: 10.1016/s1521-6918(03)00074-x. [DOI] [PubMed] [Google Scholar]
  19. Gill Harsharnjit S. Probiotics to enhance anti-infective defences in the gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2003 Oct;17(5):755–773. doi: 10.1016/s1521-6918(03)00074-x. [DOI] [PubMed] [Google Scholar]
  20. Gionchetti P., Rizzello F., Venturi A., Brigidi P., Matteuzzi D., Bazzocchi G., Poggioli G., Miglioli M., Campieri M. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology. 2000 Aug;119(2):305–309. doi: 10.1053/gast.2000.9370. [DOI] [PubMed] [Google Scholar]
  21. Gionchetti Paolo, Rizzello Fernando, Helwig Ulf, Venturi Alessandro, Lammers Karen Manon, Brigidi Patrizia, Vitali Beatrice, Poggioli Gilberto, Miglioli Mario, Campieri Massimo. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology. 2003 May;124(5):1202–1209. doi: 10.1016/s0016-5085(03)00171-9. [DOI] [PubMed] [Google Scholar]
  22. Glenn F., Reed C., Grafe W. R. Biliary enteric fistula. Surg Gynecol Obstet. 1981 Oct;153(4):527–531. [PubMed] [Google Scholar]
  23. Guslandi M., Mezzi G., Sorghi M., Testoni P. A. Saccharomyces boulardii in maintenance treatment of Crohn's disease. Dig Dis Sci. 2000 Jul;45(7):1462–1464. doi: 10.1023/a:1005588911207. [DOI] [PubMed] [Google Scholar]
  24. Hart A. L., Stagg A. J., Frame M., Graffner H., Glise H., Falk P., Kamm M. A. The role of the gut flora in health and disease, and its modification as therapy. Aliment Pharmacol Ther. 2002 Aug;16(8):1383–1393. doi: 10.1046/j.1365-2036.2002.01310.x. [DOI] [PubMed] [Google Scholar]
  25. Helin T., Haahtela S., Haahtela T. No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study. Allergy. 2002 Mar;57(3):243–246. doi: 10.1034/j.1398-9995.2002.1s3299.x. [DOI] [PubMed] [Google Scholar]
  26. Hession P. R., Rawlinson J., Hall J. R., Keating J. P., Guyer P. B. The clinical and radiological features of cholecystocolic fistulae. Br J Radiol. 1996 Sep;69(825):804–809. doi: 10.1259/0007-1285-69-825-804. [DOI] [PubMed] [Google Scholar]
  27. Heyman M. Symposium on 'dietary influences on mucosal immunity'. How dietary antigens access the mucosal immune system. Proc Nutr Soc. 2001 Nov;60(4):419–426. [PubMed] [Google Scholar]
  28. Holzapfel W. H., Haberer P., Snel J., Schillinger U., Huis in't Veld J. H. Overview of gut flora and probiotics. Int J Food Microbiol. 1998 May 26;41(2):85–101. doi: 10.1016/s0168-1605(98)00044-0. [DOI] [PubMed] [Google Scholar]
  29. Hooper L. V., Gordon J. I. Commensal host-bacterial relationships in the gut. Science. 2001 May 11;292(5519):1115–1118. doi: 10.1126/science.1058709. [DOI] [PubMed] [Google Scholar]
  30. Huang Jeannie S., Bousvaros Athos, Lee John W., Diaz Angela, Davidson Emily J. Efficacy of probiotic use in acute diarrhea in children: a meta-analysis. Dig Dis Sci. 2002 Nov;47(11):2625–2634. doi: 10.1023/a:1020501202369. [DOI] [PubMed] [Google Scholar]
  31. Isolauri E., Arvola T., Sütas Y., Moilanen E., Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy. 2000 Nov;30(11):1604–1610. doi: 10.1046/j.1365-2222.2000.00943.x. [DOI] [PubMed] [Google Scholar]
  32. Isolauri E., Joensuu J., Suomalainen H., Luomala M., Vesikari T. Improved immunogenicity of oral D x RRV reassortant rotavirus vaccine by Lactobacillus casei GG. Vaccine. 1995 Feb;13(3):310–312. doi: 10.1016/0264-410x(95)93319-5. [DOI] [PubMed] [Google Scholar]
  33. Kaila M., Isolauri E., Saxelin M., Arvilommi H., Vesikari T. Viable versus inactivated lactobacillus strain GG in acute rotavirus diarrhoea. Arch Dis Child. 1995 Jan;72(1):51–53. doi: 10.1136/adc.72.1.51. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Kaila M., Isolauri E., Soppi E., Virtanen E., Laine S., Arvilommi H. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res. 1992 Aug;32(2):141–144. doi: 10.1203/00006450-199208000-00002. [DOI] [PubMed] [Google Scholar]
  35. Kalliomäki M., Kirjavainen P., Eerola E., Kero P., Salminen S., Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol. 2001 Jan;107(1):129–134. doi: 10.1067/mai.2001.111237. [DOI] [PubMed] [Google Scholar]
  36. Kalliomäki M., Salminen S., Arvilommi H., Kero P., Koskinen P., Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet. 2001 Apr 7;357(9262):1076–1079. doi: 10.1016/S0140-6736(00)04259-8. [DOI] [PubMed] [Google Scholar]
  37. Kalliomäki Marko, Salminen Seppo, Poussa Tuija, Arvilommi Heikki, Isolauri Erika. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet. 2003 May 31;361(9372):1869–1871. doi: 10.1016/S0140-6736(03)13490-3. [DOI] [PubMed] [Google Scholar]
  38. Kawase M., Hashimoto H., Hosoda M., Morita H., Hosono A. Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci. 2000 Feb;83(2):255–263. doi: 10.3168/jds.S0022-0302(00)74872-7. [DOI] [PubMed] [Google Scholar]
  39. Kennedy R. J., Hoper M., Deodhar K., Kirk S. J., Gardiner K. R. Probiotic therapy fails to improve gut permeability in a hapten model of colitis. Scand J Gastroenterol. 2000 Dec;35(12):1266–1271. doi: 10.1080/003655200453601. [DOI] [PubMed] [Google Scholar]
  40. Kiessling G., Schneider J., Jahreis G. Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol. Eur J Clin Nutr. 2002 Sep;56(9):843–849. doi: 10.1038/sj.ejcn.1601399. [DOI] [PubMed] [Google Scholar]
  41. Kim H. J., Camilleri M., McKinzie S., Lempke M. B., Burton D. D., Thomforde G. M., Zinsmeister A. R. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2003 Apr 1;17(7):895–904. doi: 10.1046/j.1365-2036.2003.01543.x. [DOI] [PubMed] [Google Scholar]
  42. Kirjavainen Pirkka V., Salminen Seppo J., Isolauri Erika. Probiotic bacteria in the management of atopic disease: underscoring the importance of viability. J Pediatr Gastroenterol Nutr. 2003 Feb;36(2):223–227. doi: 10.1097/00005176-200302000-00012. [DOI] [PubMed] [Google Scholar]
  43. Kolars J. C., Levitt M. D., Aouji M., Savaiano D. A. Yogurt--an autodigesting source of lactose. N Engl J Med. 1984 Jan 5;310(1):1–3. doi: 10.1056/NEJM198401053100101. [DOI] [PubMed] [Google Scholar]
  44. Kruis W., Schütz E., Fric P., Fixa B., Judmaier G., Stolte M. Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther. 1997 Oct;11(5):853–858. doi: 10.1046/j.1365-2036.1997.00225.x. [DOI] [PubMed] [Google Scholar]
  45. Kuisma J., Mentula S., Jarvinen H., Kahri A., Saxelin M., Farkkila M. Effect of Lactobacillus rhamnosus GG on ileal pouch inflammation and microbial flora. Aliment Pharmacol Ther. 2003 Feb 15;17(4):509–515. doi: 10.1046/j.1365-2036.2003.01465.x. [DOI] [PubMed] [Google Scholar]
  46. Labayen I., Forga L., González A., Lenoir-Wijnkoop I., Nutr R., Martínez J. A. Relationship between lactose digestion, gastrointestinal transit time and symptoms in lactose malabsorbers after dairy consumption. Aliment Pharmacol Ther. 2001 Apr;15(4):543–549. doi: 10.1046/j.1365-2036.2001.00952.x. [DOI] [PubMed] [Google Scholar]
  47. Lerebours E., N'Djitoyap Ndam C., Lavoine A., Hellot M. F., Antoine J. M., Colin R. Yogurt and fermented-then-pasteurized milk: effects of short-term and long-term ingestion on lactose absorption and mucosal lactase activity in lactase-deficient subjects. Am J Clin Nutr. 1989 May;49(5):823–827. doi: 10.1093/ajcn/49.5.823. [DOI] [PubMed] [Google Scholar]
  48. Lichtman S. M. Bacterial [correction of baterial] translocation in humans. J Pediatr Gastroenterol Nutr. 2001 Jul;33(1):1–10. doi: 10.1097/00005176-200107000-00001. [DOI] [PubMed] [Google Scholar]
  49. Lin S. Y., Ayres J. W., Winkler W., Jr, Sandine W. E. Lactobacillus effects on cholesterol: in vitro and in vivo results. J Dairy Sci. 1989 Nov;72(11):2885–2899. doi: 10.3168/jds.S0022-0302(89)79439-X. [DOI] [PubMed] [Google Scholar]
  50. Link-Amster H., Rochat F., Saudan K. Y., Mignot O., Aeschlimann J. M. Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunol Med Microbiol. 1994 Nov;10(1):55–63. doi: 10.1111/j.1574-695X.1994.tb00011.x. [DOI] [PubMed] [Google Scholar]
  51. Lodinová-Zádníková Rája, Cukrowska Bozena, Tlaskalova-Hogenova Helena. Oral administration of probiotic Escherichia coli after birth reduces frequency of allergies and repeated infections later in life (after 10 and 20 years). Int Arch Allergy Immunol. 2003 Jul;131(3):209–211. doi: 10.1159/000071488. [DOI] [PubMed] [Google Scholar]
  52. Loskutova I. E. Effektivnost' primeneniia adaptirovannykh propionovo-atsido-fil'nykh smesei "Maliutka" i "Malysh" v kompleksnom lechenii vrozhdennoi gipotrofii. Vopr Pitan. 1985 May-Jun;(3):17–20. [PubMed] [Google Scholar]
  53. Macpherson A., Khoo U. Y., Forgacs I., Philpott-Howard J., Bjarnason I. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut. 1996 Mar;38(3):365–375. doi: 10.1136/gut.38.3.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Madsen K., Cornish A., Soper P., McKaigney C., Jijon H., Yachimec C., Doyle J., Jewell L., De Simone C. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology. 2001 Sep;121(3):580–591. doi: 10.1053/gast.2001.27224. [DOI] [PubMed] [Google Scholar]
  55. Majamaa H., Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol. 1997 Feb;99(2):179–185. doi: 10.1016/s0091-6749(97)70093-9. [DOI] [PubMed] [Google Scholar]
  56. Majamaa H., Isolauri E., Saxelin M., Vesikari T. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 1995 Apr;20(3):333–338. doi: 10.1097/00005176-199504000-00012. [DOI] [PubMed] [Google Scholar]
  57. Malchow H. A. Crohn's disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn's disease? J Clin Gastroenterol. 1997 Dec;25(4):653–658. doi: 10.1097/00004836-199712000-00021. [DOI] [PubMed] [Google Scholar]
  58. Mann G. V. Studies of a surfactant and cholesteremia in the Maasai. Am J Clin Nutr. 1974 May;27(5):464–469. doi: 10.1093/ajcn/27.5.464. [DOI] [PubMed] [Google Scholar]
  59. Marteau P., Flourie B., Pochart P., Chastang C., Desjeux J. F., Rambaud J. C. Effect of the microbial lactase (EC 3.2.1.23) activity in yoghurt on the intestinal absorption of lactose: an in vivo study in lactase-deficient humans. Br J Nutr. 1990 Jul;64(1):71–79. doi: 10.1079/bjn19900010. [DOI] [PubMed] [Google Scholar]
  60. Marteau P., Seksik P., Jian R. Probiotics and intestinal health effects: a clinical perspective. Br J Nutr. 2002 Sep;88 (Suppl 1):S51–S57. doi: 10.1079/BJN2002629. [DOI] [PubMed] [Google Scholar]
  61. Marteau P., Seksik P., Jian R. Probiotics and intestinal health effects: a clinical perspective. Br J Nutr. 2002 Sep;88 (Suppl 1):S51–S57. doi: 10.1079/BJN2002629. [DOI] [PubMed] [Google Scholar]
  62. Mastretta Emmanuele, Longo Patrizia, Laccisaglia Anna, Balbo Luciano, Russo Roberto, Mazzaccara Alfonso, Gianino Paola. Effect of Lactobacillus GG and breast-feeding in the prevention of rotavirus nosocomial infection. J Pediatr Gastroenterol Nutr. 2002 Oct;35(4):527–531. doi: 10.1097/00005176-200210000-00013. [DOI] [PubMed] [Google Scholar]
  63. Matricardi P. M., Rosmini F., Rapicetta M., Gasbarrini G., Stroffolini T. Atopy, hygiene, and anthroposophic lifestyle. San Marino Study Group. Lancet. 1999 Jul 31;354(9176):430–430. doi: 10.1016/s0140-6736(05)75853-0. [DOI] [PubMed] [Google Scholar]
  64. Meydani S. N., Ha W. K. Immunologic effects of yogurt. Am J Clin Nutr. 2000 Apr;71(4):861–872. doi: 10.1093/ajcn/71.4.861. [DOI] [PubMed] [Google Scholar]
  65. Mikes A., Ferencík M., Jahnová E., Ebringer L., Ciznár I. Hypocholesterolemic and immunostimulatory effects of orally applied Enterococcus faecium M-74 in man. Folia Microbiol (Praha) 1995;40(6):639–646. doi: 10.1007/BF02818522. [DOI] [PubMed] [Google Scholar]
  66. Nobaek S., Johansson M. L., Molin G., Ahrné S., Jeppsson B. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol. 2000 May;95(5):1231–1238. doi: 10.1111/j.1572-0241.2000.02015.x. [DOI] [PubMed] [Google Scholar]
  67. Oberhelman R. A., Gilman R. H., Sheen P., Taylor D. N., Black R. E., Cabrera L., Lescano A. G., Meza R., Madico G. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children. J Pediatr. 1999 Jan;134(1):15–20. doi: 10.1016/s0022-3476(99)70366-5. [DOI] [PubMed] [Google Scholar]
  68. Oláh A., Belágyi T., Issekutz A., Gamal M. E., Bengmark S. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg. 2002 Sep;89(9):1103–1107. doi: 10.1046/j.1365-2168.2002.02189.x. [DOI] [PubMed] [Google Scholar]
  69. Pedone C. A., Arnaud C. C., Postaire E. R., Bouley C. F., Reinert P. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea. Int J Clin Pract. 2000 Nov;54(9):568–571. [PubMed] [Google Scholar]
  70. Pelletier X., Laure-Boussuge S., Donazzolo Y. Hydrogen excretion upon ingestion of dairy products in lactose-intolerant male subjects: importance of the live flora. Eur J Clin Nutr. 2001 Jun;55(6):509–512. doi: 10.1038/sj.ejcn.1601169. [DOI] [PubMed] [Google Scholar]
  71. Pelto L., Isolauri E., Lilius E. M., Nuutila J., Salminen S. Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects. Clin Exp Allergy. 1998 Dec;28(12):1474–1479. doi: 10.1046/j.1365-2222.1998.00449.x. [DOI] [PubMed] [Google Scholar]
  72. Pessi T., Sütas Y., Hurme M., Isolauri E. Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clin Exp Allergy. 2000 Dec;30(12):1804–1808. doi: 10.1046/j.1365-2222.2000.00948.x. [DOI] [PubMed] [Google Scholar]
  73. Pirzer U., Schönhaar A., Fleischer B., Hermann E., Meyer zum Büschenfelde K. H. Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet. 1991 Nov 16;338(8777):1238–1239. doi: 10.1016/0140-6736(91)92104-a. [DOI] [PubMed] [Google Scholar]
  74. Prantera C., Scribano M. L., Falasco G., Andreoli A., Luzi C. Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG. Gut. 2002 Sep;51(3):405–409. doi: 10.1136/gut.51.3.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Rautava Samuli, Kalliomäki Marko, Isolauri Erika. Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. J Allergy Clin Immunol. 2002 Jan;109(1):119–121. doi: 10.1067/mai.2002.120273. [DOI] [PubMed] [Google Scholar]
  76. Rayes Nada, Seehofer Daniel, Hansen Sonja, Boucsein Kathrin, Müller Andrea Raffaela, Serke Stefan, Bengmark Stig, Neuhaus Peter. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation. 2002 Jul 15;74(1):123–127. doi: 10.1097/00007890-200207150-00021. [DOI] [PubMed] [Google Scholar]
  77. Rembacken B. J., Snelling A. M., Hawkey P. M., Chalmers D. M., Axon A. T. Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet. 1999 Aug 21;354(9179):635–639. doi: 10.1016/s0140-6736(98)06343-0. [DOI] [PubMed] [Google Scholar]
  78. Richelsen B., Kristensen K., Pedersen S. B. Long-term (6 months) effect of a new fermented milk product on the level of plasma lipoproteins--a placebo-controlled and double blind study. Eur J Clin Nutr. 1996 Dec;50(12):811–815. [PubMed] [Google Scholar]
  79. Rizkalla S. W., Luo J., Kabir M., Chevalier A., Pacher N., Slama G. Chronic consumption of fresh but not heated yogurt improves breath-hydrogen status and short-chain fatty acid profiles: a controlled study in healthy men with or without lactose maldigestion. Am J Clin Nutr. 2000 Dec;72(6):1474–1479. doi: 10.1093/ajcn/72.6.1474. [DOI] [PubMed] [Google Scholar]
  80. Saavedra J. M., Bauman N. A., Oung I., Perman J. A., Yolken R. H. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet. 1994 Oct 15;344(8929):1046–1049. doi: 10.1016/s0140-6736(94)91708-6. [DOI] [PubMed] [Google Scholar]
  81. Savaiano D. A., AbouElAnouar A., Smith D. E., Levitt M. D. Lactose malabsorption from yogurt, pasteurized yogurt, sweet acidophilus milk, and cultured milk in lactase-deficient individuals. Am J Clin Nutr. 1984 Dec;40(6):1219–1223. doi: 10.1093/ajcn/40.6.1219. [DOI] [PubMed] [Google Scholar]
  82. Schaafsma G., Meuling W. J., van Dokkum W., Bouley C. Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. Eur J Clin Nutr. 1998 Jun;52(6):436–440. doi: 10.1038/sj.ejcn.1600583. [DOI] [PubMed] [Google Scholar]
  83. Schiffrin E. J., Rochat F., Link-Amster H., Aeschlimann J. M., Donnet-Hughes A. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci. 1995 Mar;78(3):491–497. doi: 10.3168/jds.S0022-0302(95)76659-0. [DOI] [PubMed] [Google Scholar]
  84. Schultz Michael, Veltkamp Claudia, Dieleman Levinus A., Grenther Wetonia B., Wyrick Pricilla B., Tonkonogy Susan L., Sartor R. Balfour. Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice. Inflamm Bowel Dis. 2002 Mar;8(2):71–80. doi: 10.1097/00054725-200203000-00001. [DOI] [PubMed] [Google Scholar]
  85. Sheih Y. H., Chiang B. L., Wang L. H., Liao C. K., Gill H. S. Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. J Am Coll Nutr. 2001 Apr;20(2 Suppl):149–156. doi: 10.1080/07315724.2001.10719027. [DOI] [PubMed] [Google Scholar]
  86. Sheu B-S, Wu J-J, Lo C-Y, Wu H-W, Chen J-H, Lin Y-S, Lin M-D. Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther. 2002 Sep;16(9):1669–1675. doi: 10.1046/j.1365-2036.2002.01335.x. [DOI] [PubMed] [Google Scholar]
  87. Spanhaak S., Havenaar R., Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr. 1998 Dec;52(12):899–907. doi: 10.1038/sj.ejcn.1600663. [DOI] [PubMed] [Google Scholar]
  88. Steidler L., Hans W., Schotte L., Neirynck S., Obermeier F., Falk W., Fiers W., Remaut E. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science. 2000 Aug 25;289(5483):1352–1355. doi: 10.1126/science.289.5483.1352. [DOI] [PubMed] [Google Scholar]
  89. Szajewska H., Kotowska M., Mrukowicz J. Z., Armańska M., Mikołajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr. 2001 Mar;138(3):361–365. doi: 10.1067/mpd.2001.111321. [DOI] [PubMed] [Google Scholar]
  90. Szajewska H., Mrukowicz J. Z. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr. 2001 Oct;33 (Suppl 2):S17–S25. doi: 10.1097/00005176-200110002-00004. [DOI] [PubMed] [Google Scholar]
  91. Szajewska H., Mrukowicz J. Z. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr. 2001 Oct;33 (Suppl 2):S17–S25. doi: 10.1097/00005176-200110002-00004. [DOI] [PubMed] [Google Scholar]
  92. Tamboli Cyrus P., Caucheteux Christel, Cortot Antoine, Colombel Jean-Frédéric, Desreumaux Pierre. Probiotics in inflammatory bowel disease: a critical review. Best Pract Res Clin Gastroenterol. 2003 Oct;17(5):805–820. doi: 10.1016/s1521-6918(03)00076-3. [DOI] [PubMed] [Google Scholar]
  93. Tamboli Cyrus P., Caucheteux Christel, Cortot Antoine, Colombel Jean-Frédéric, Desreumaux Pierre. Probiotics in inflammatory bowel disease: a critical review. Best Pract Res Clin Gastroenterol. 2003 Oct;17(5):805–820. doi: 10.1016/s1521-6918(03)00076-3. [DOI] [PubMed] [Google Scholar]
  94. Teitelbaum Jonathan E., Walker W. Allan. Nutritional impact of pre- and probiotics as protective gastrointestinal organisms. Annu Rev Nutr. 2002 Jan 4;22:107–138. doi: 10.1146/annurev.nutr.22.110901.145412. [DOI] [PubMed] [Google Scholar]
  95. Teitelbaum Jonathan E., Walker W. Allan. Nutritional impact of pre- and probiotics as protective gastrointestinal organisms. Annu Rev Nutr. 2002 Jan 4;22:107–138. doi: 10.1146/annurev.nutr.22.110901.145412. [DOI] [PubMed] [Google Scholar]
  96. Van 't Veer P., van Leer E. M., Rietdijk A., Kok F. J., Schouten E. G., Hermus R. J., Sturmans F. Combination of dietary factors in relation to breast-cancer occurrence. Int J Cancer. 1991 Mar 12;47(5):649–653. doi: 10.1002/ijc.2910470503. [DOI] [PubMed] [Google Scholar]
  97. Van Niel Cornelius W., Feudtner Chris, Garrison Michelle M., Christakis Dimitri A. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. Pediatrics. 2002 Apr;109(4):678–684. doi: 10.1542/peds.109.4.678. [DOI] [PubMed] [Google Scholar]
  98. Varela-Moreiras G., Antoine J. M., Ruiz-Roso B., Varela G. Effects of yogurt and fermented-then-pasteurized milk on lactose absorption in an institutionalized elderly group. J Am Coll Nutr. 1992 Apr;11(2):168–171. [PubMed] [Google Scholar]
  99. Videla S., Vilaseca J., Antolín M., García-Lafuente A., Guarner F., Crespo E., Casalots J., Salas A., Malagelada J. R. Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat. Am J Gastroenterol. 2001 May;96(5):1486–1493. doi: 10.1111/j.1572-0241.2001.03802.x. [DOI] [PubMed] [Google Scholar]
  100. Welters Carlo F. M., Heineman Erik, Thunnissen Frederik B. J. M., van den Bogaard Anthony E. J. M., Soeters Peter B., Baeten Cor G. M. I. Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. Dis Colon Rectum. 2002 May;45(5):621–627. doi: 10.1007/s10350-004-6257-2. [DOI] [PubMed] [Google Scholar]
  101. Wendakoon Chitra N., Thomson Alan B. R., Ozimek Lech. Lack of therapeutic effect of a specially designed yogurt for the eradication of Helicobacter pylori infection. Digestion. 2002;65(1):16–20. doi: 10.1159/000051926. [DOI] [PubMed] [Google Scholar]
  102. Wheeler J. G., Shema S. J., Bogle M. L., Shirrell M. A., Burks A. W., Pittler A., Helm R. M. Immune and clinical impact of Lactobacillus acidophilus on asthma. Ann Allergy Asthma Immunol. 1997 Sep;79(3):229–233. doi: 10.1016/S1081-1206(10)63007-4. [DOI] [PubMed] [Google Scholar]
  103. Yasui H., Mike A., Ohwaki M. Immunogenicity of Bifidobacterium breve and change in antibody production in Peyer's patches after oral administration. J Dairy Sci. 1989 Jan;72(1):30–35. doi: 10.3168/jds.S0022-0302(89)79076-7. [DOI] [PubMed] [Google Scholar]
  104. de Roos N. M., Schouten G., Katan M. B. Yoghurt enriched with Lactobacillus acidophilus does not lower blood lipids in healthy men and women with normal to borderline high serum cholesterol levels. Eur J Clin Nutr. 1999 Apr;53(4):277–280. doi: 10.1038/sj.ejcn.1600722. [DOI] [PubMed] [Google Scholar]
  105. de Vrese M., Stegelmann A., Richter B., Fenselau S., Laue C., Schrezenmeir J. Probiotics--compensation for lactase insufficiency. Am J Clin Nutr. 2001 Feb;73(2 Suppl):421S–429S. doi: 10.1093/ajcn/73.2.421s. [DOI] [PubMed] [Google Scholar]
  106. van't Veer P., Dekker J. M., Lamers J. W., Kok F. J., Schouten E. G., Brants H. A., Sturmans F., Hermus R. J. Consumption of fermented milk products and breast cancer: a case-control study in The Netherlands. Cancer Res. 1989 Jul 15;49(14):4020–4023. [PubMed] [Google Scholar]
  107. von der Weid T., Bulliard C., Schiffrin E. J. Induction by a lactic acid bacterium of a population of CD4(+) T cells with low proliferative capacity that produce transforming growth factor beta and interleukin-10. Clin Diagn Lab Immunol. 2001 Jul;8(4):695–701. doi: 10.1128/CDLI.8.4.695-701.2001. [DOI] [PMC free article] [PubMed] [Google Scholar]

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