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. 2006 Nov 29;103(50):19170–19175. doi: 10.1073/pnas.0608644103

Fig. 4.

Fig. 4.

Prevention of sleep deprivation-associated reduction of cell proliferation by CORT normalization. Adult rats underwent bilateral surgical removal of the adrenal glands (ADX) or were Sham-operated. All ADX-treated rats were given drinking water containing CORT (25 μg/ml in 0.9% saline). One week after surgery, ADX and Sham rats either remained as controls (Sham/CC, n = 5; ADX+CORT/CC, n = 5) or were exposed to 72 h on SPs (Sham/SP, n = 7; ADX+CORT/SP, n = 4). Thereafter, all rats received a single injection of BrdU (200 mg/kg, i.p.) and were perfused 2 h later. The suppression of cell proliferation normally associated with extended sleep loss was observed in Sham/SP but not ADX+CORT/SP rats; that is, fewer BrdU-labeled cells were observed in Sham/SP rats compared with all other groups. Error bars indicate SEM; ∗, P < 0.05 compared with control.