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. 2006 Dec 1;103(50):19176–19181. doi: 10.1073/pnas.0606373103

Fig. 1.

Fig. 1.

Increased trimethylation of histone H3 [TMH-H3 (K9)] and altered ESET/SETDB1 expression are found in striatal neurons of HD patients. Immunocytochemical staining for TMH-H3 (K9) (A–C) and ESET (D–F) is markedly increased in the caudate nucleus of HD grades 2 (B and E) and 3 (C and F) brains compared with control brains displaying weak expression of TMH-H3 (K9) (A) and ESET (D). (Scale bars, 100 μm.) (G) Immunoreactivity of ESET is colocalized with NeuN immunoreactivity in caudate neurons in brains from HD patients. (H) Western blots show increased TMH-H3 (K9) and ESET protein expression in the caudate tissue from HD patients (Left). Densitometric analysis of ESET protein levels in control (n = 5) and HD (n = 5) (Right). ∗, Significantly different from control at P < 0.05.