Abstract
Terbinafine, an allylamine derivative, represents the most effective of this new chemical class of antimycotic compounds. Under in vitro conditions, terbinafine proved to be highly active against dermatophytes (MIC range, 0.001 to 0.01 microgram/ml), aspergilli (MIC range, 0.05 to 1.56 micrograms/ml), and Sporothrix schenckii (MIC range, 0.1 to 0.4 microgram/ml) and also exerted good activity against yeasts (MIC range, 0.1 to greater than 100 micrograms/ml). The growth of Malassezia furfur was inhibited also (MIC range, 0.2 to 0.8 microgram/ml). Terbinafine displays a primary fungicidal action against dermatophytes, other filamentous fungi, and S. schenckii. The type of action against yeasts is species dependent and can be primarily fungicidal (Candida parapsilosis) or fungistatic (Candida albicans). The in vitro activity of terbinafine is pH dependent and rises with increasing pH value.
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Selected References
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- Faergemann J. Tinea versicolor and Pityrosporum orbiculare: mycological investigations, experimental infections and epidemiological surveys. Acta Derm Venereol Suppl (Stockh) 1979;(86):1–23. [PubMed] [Google Scholar]
- Georgopoulos A., Petranyi G., Mieth H., Drews J. In vitro activity of naftifine, a new antifungal agent. Antimicrob Agents Chemother. 1981 Mar;19(3):386–389. doi: 10.1128/aac.19.3.386. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Georgopoulos A. Tiefgefriekonservierung von Pilzen in flüssigem Stickstoff als Grundlage für standardisierte Inokula. Mykosen. 1978 Jan;21(1):19–23. [PubMed] [Google Scholar]
- Goudard M., Buffard Y., Ferrari H., Regli P. Spectre d'action in vitro d'un nouvel antifongique dérivé de la naftifine: la terbinafine (SF 86-327). Pathol Biol (Paris) 1986 Jun;34(5 Pt 2):680–683. [PubMed] [Google Scholar]
- Petranyi G., Georgopoulos A., Mieth H. In vivo antimycotic activity of naftifine. Antimicrob Agents Chemother. 1981 Mar;19(3):390–392. doi: 10.1128/aac.19.3.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Petranyi G., Ryder N. S., Stütz A. Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science. 1984 Jun 15;224(4654):1239–1241. doi: 10.1126/science.6547247. [DOI] [PubMed] [Google Scholar]
- Ryder N. S., Dupont M. C. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes. Biochem J. 1985 Sep 15;230(3):765–770. doi: 10.1042/bj2300765. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ryder N. S. Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent. Antimicrob Agents Chemother. 1985 Feb;27(2):252–256. doi: 10.1128/aac.27.2.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shadomy S., Espinel-Ingroff A., Gebhart R. J. In-vitro studies with SF 86-327, a new orally active allylamine derivative. Sabouraudia. 1985 Apr;23(2):125–132. doi: 10.1080/00362178585380201. [DOI] [PubMed] [Google Scholar]
- Stütz A., Georgopoulos A., Granitzer W., Petranyi G., Berney D. Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics. J Med Chem. 1986 Jan;29(1):112–125. doi: 10.1021/jm00151a019. [DOI] [PubMed] [Google Scholar]
- Stütz A., Petranyi G. Synthesis and antifungal activity of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphtha lenemethanamine (SF 86-327) and related allylamine derivatives with enhanced oral activity. J Med Chem. 1984 Dec;27(12):1539–1543. doi: 10.1021/jm00378a003. [DOI] [PubMed] [Google Scholar]