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. 1987 Nov;31(11):1831–1840. doi: 10.1128/aac.31.11.1831

Computer automated structure evaluation of quinolone antibacterial agents.

G Klopman 1, O T Macina 1, M E Levinson 1, H S Rosenkranz 1
PMCID: PMC175048  PMID: 2829716

Abstract

The Computer Automated Structure Evaluation (CASE) program was used to study a series of quinolone antibacterial agents for which experimental data pertaining to DNA gyrase inhibition as well as MICs against several strains of gram-positive and gram-negative bacteria are available. The result of the analysis was the automatic generation of molecular fragments relevant to the respective biological endpoints. The potential significance of these major activating-inactivating fragments to the biological activity is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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