Table 3.

Average peak ionic current and Ca²⁺ conductance parameters restored by RyR1–RyR3 chimerae in dyspedic primary myotubes

Construct	No. of cells	Average peak ICa2+, pA/pF ± SE	Gmax, nS/nF ± SE	V1/2, mV ± SE	K, mV ± SE
RyR1	14	−6.6 ± 1.3	169 ± 21	16 ± 2	4.5 ± 0.4
RyR1+D2	9	−8.7 ± 1.5	228 ± 27	17 ± 2	5.2 ± 0.5
Ch-4rev	13	−5.3 ± 0.8	167 ± 11	18 ± 1	4.8 ± 0.4
Ch-4	10	−4.6 ± 1.0	167 ± 20	21 ± 2	4.9 ± 0.4
Ch-2rev+D2	9	−3.5 ± 0.8	136 ± 12	19 ± 2	5.5 ± 0.4
Ch-4+D2	15	−4.2 ± 0.5	133 ± 12	17 ± 1	4.8 ± 0.3
RyR3+D2	15	−3.9 ± 0.5	123 ± 12	16 ± 1	4.8 ± 0.3
Ch-2	15	−3.4 ± 0.5*	121 ± 14	21 ± 1	4.6 ± 0.4
RyR1−D2	13	−2.8 ± 0.4*	106 ± 12*	19 ± 1	4.7 ± 0.5
Ch-2rev	10	−3.2 ± 0.8*	91 ± 15*	20 ± 2	5.0 ± 0.5
RyR3	10	−3.0 ± 0.8*	94 ± 11*	22 ± 2	5.2 ± 0.5
Dyspedic	6	−1.0 ± 0.3#	61 ± 6†	22 ± 2	5.2 ± 0.2

Significance values are in comparison to RyR1 and are as follows:

*, P < 0.05;

†, P < 0.01.