Table 1.
Baseline patient characteristics based on the time to treatment
| Parameter | 0–24 hours (n = 29) | >24 hours (n = 11) | P value |
| Age (years) | 51.5 ± 17.6 | 67.4 ± 9.9 | 0.008a |
| Male sex | 13 (45%) | 3 (27%) | 0.31b |
| Acute Physiology and Chronic Health Evaluation II score | 23.9 ± 5.5 | 26.9 ± 9.8 | 0.22a |
| Time from first organ dysfunction to start of treatment (hours) | 12.2 ± 6.8 | 45.7 ± 21.8 | <0.0001a |
| Number of organ dysfunctions | 3.6 ± 1.2 | 3.3 ± 1.3 | 0.55a |
| Mechanical ventilation | 25 (86%) | 11 (100%) | 0.19b |
| Vasopressors | 28 (97%) | 10 (91%) | 0.47b |
| Recent surgery | 8 (28%) | 6 (55%) | 0.13b |
| Primary site of infection | |||
| Respiratory system | 13 (45%) | 1 (9%) | 0.03b |
| Abdominal | 8 (28%) | 5 (45%) | 0.28b |
| Urogenital | 2 (7%) | 2 (18%) | 0.29b |
| Other | 6 (2%) | 3 (27%) | 0.66b |
Data presented as mean ± standard deviation or as n (%). aStudent's t test. bChi-square test.