Table 2.
Effects of in vivo lipopolysaccharide (LPS) on isolated and perfused hearts of young rats and senescent rats
| Young rats (3 months old) | Senescent rats (24 months old) | ||||
| Control group (n = 8) | LPS 0.5 mg/kg group (n = 9) | LPS 5 mg/kg group (n = 9) | Control group (n = 11) | LPS 0.5 mg/kg group (n = 13) | |
| LVDP (mmHg/g HW) | 100 ± 7 | 64 ± 6* | 48 ± 7* | 53 ± 4 | 25 ± 4* |
| dP/dtmax (mmHg/s/g HW) | 2744 ± 186 | 1611 ± 138* | 1216 ± 152* | 1804 ± 260 | 893 ± 158* |
| -dP/dtmax (mmHg/s/g HW) | -1863 ± 61 | -1320 ± 116* | -1058 ± 103* | -919 ± 91 | -480 ± 59* |
| Coronary flow (ml/minute/g HW) | 14 ± 2 | 14 ± 1 | 13 ± 2 | 10 ± 1 | 12 ± 1 |
Values are the mean ± standard error of the mean. LVDP, left ventricular developed pressure; dP/dtmax, peak of the positive pressure derivative; -dP/dtmax, peak of the negative pressure derivative. *P < 0.05 versus respective control (saline-injected) group.