Table 2.
Demographic data and genotype frequencies of TNF and IL-10 polymorphisms in patients with sepsis and controls.
| Patients (n = 224) | Control individuals (n = 101) | |
| Age | 63.5 (49–72.75) | 50 (46.5–55.5) |
| APACHE II | 14 (9–19) | - |
| SOFA (1)a | 4 (2–9) | - |
| -308 TNF-α promoter polymorphism | ||
| GG | 186 (83) | 82 (81.2) |
| GA | 35 (15.6) | 15 (14.9) |
| AA | 3 (1.4) | 4 (3.9) |
| TNF-β (NcoI polymorphism) | ||
| GG | 16 (7.1) | 10 (9.9) |
| GA | 69 (30.8) | 34 (33.7) |
| AA | 139 (62.5) | 57 (56.4) |
| IL-10-1082 | ||
| GG | 33 (14.8) | 15 (14.8) |
| GA | 99 (44.2) | 50 (49.5) |
| AA | 92 (41) | 36 (35.7) |
Values are expressed as median (25th to 75th percentile) or as n (%).aSOFA (1) means SOFA score of the first 24 hours in the hospital. APACHE, Acute Physiology and Chronic Health Evaluation score; SOFA, Sequential Organ Failure Assessment; TNF, tumour necrosis factor.