Table 5.
Bivariate analysis of risk factors for in-hospital mortality in patients with septic shock
| Factor | Nonsurvivors (n = 49) | Survivors (n = 65) | RR (95% CI) | P |
| Sex | 0.07 | |||
| Male | 18 (36.7) | 35 (43.9) | ||
| Female | 31 (63.3) | 30 (46.1) | ||
| Age (years)a | 62.5 (55–75) | 60 (45–72) | 0.11 | |
| Hepatic cirrhosis | 5 (10.2) | 4 (6.2) | 1.73 (0.35–9.21) | 0.32 |
| Immunosuppression | 4 (8.2) | 2 (3.1) | 2.8 (0.38–31.92) | 0.21 |
| COPD | 5 (10.2) | 5 (7.7) | 1.36 (0.29–6.30) | 0.42 |
| End-stage renal disease | 5 (10.2) | 3 (4.6) | 2.35 (0.43–15.79) | 0.21 |
| Chronic cardiac failure | 2 (4.1) | 2 (3.1) | 1.34 (0.09–19.07) | 0.58 |
| Diabetes mellitus | 13 (26.5) | 18 (27.7) | 0.94 (0.38–2.35) | 0.89 |
| Noncured malignancy | 6 (12.2) | 1 (1.5) | 8.9 (1.01–417) | 0.24 |
| Alcoholism | 5 (10.2) | 6 (9.2) | 1.12 (0.25–4.71) | 0.55 |
| Smoking habit | 8 (16.4) | 10 15.4) | 1.07 (0.35–3.29) | 0.89 |
| APACHE IIa | 18 (14–22) | 17 (13–21) | 0.09 | |
| SOFA (1)a,b | 6.5 (3–11) | 8 (3–11) | 0.8 | |
| Bacteraemia | 13 (26.5) | 26 (40) | 0.54 (0.22–1.30) | 0.2 |
| Genotype | ||||
| -308 TNF-α promoter polymorphism | 1.80 (0.61–5.43) | 0.42 | ||
| GG | 42 (85.7) | 50 (77) | ||
| GA/AA | 7 (14.3) | 15 (23) | ||
| TNF-β (NcoI polymorphism) | 0.66 (0.26–1.39) | 0.19 | ||
| GG/GA | 16 (32.6) | 29 (44.6) | ||
| AA | 33 (67.4) | 36 (55.4) | ||
| IL-10-1082 | 0.62 (0.18–1.96) | 0.89 | ||
| GG | 6 (12.2) | 12 | ||
| GA/AA | 43 (81.8) | 53 | ||
| Genotype TNF -308 GA/AA, TNF-β AA, IL-10-1082 GG | 1.09 (0.46–2.61) | 0.65 | ||
| Yes | 16 (32.6) | 20 | ||
| No | 33 (67.4) | 45 | ||
| Delayed AATa | 7.5 (4–28.5) | 5.5 (3–12) | 0.03 | |
Unless otherwise stated, values are expressed as n (%). aResults expressed as median (25th to 75th percentiles). bSOFA (1) means SOFA score of the first 24 hours in the hospital. AAT, appropriate antibiotic therapy; APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; RR, relative risk; SOFA, Sequential Organ Failure Assessment.