Table 6.
Bivariate analysis of risk factors for impairment of the inflammatory response
| Factor | Impairment of the inflammatory response | P | ||
| Yes (n = 57) | No (n = 106) | RR (95%CI) | ||
| Sex | 0.39 (0.19–0.79) | 0.004 | ||
| Male | 25 (46.3) | 71 (67) | ||
| Female | 32 (53.7) | 35 (33) | ||
| Agea | 60 (50–72) | 61 (48–70.2) | 0.5 | |
| Hepatic cirrhosis | 8 (14) | 3 (2.8) | 5.61 (1.26–33.83) | 0.01 |
| Immunosuppression | 3 (5.3) | 3 (2.8) | 1.91 (0.25–14.67) | 0.42 |
| COPD | 3 (5.3) | 12 (11.3) | 0.44 (0.1–1.72) | 0.2 |
| End-stage renal disease | 3 (5.3) | 4 (3.8) | 1.42 (0.2–8.7) | 0.7 |
| Chronic cardiac failure | 2 (3.5) | 1 (0.94) | 3.82 (0.2–227) | 0.28 |
| Diabetes mellitus | 12 (21) | 26 (24.5) | 0.82 (0.35–1.9) | 0.61 |
| Noncured malignancy | 4 (7) | 4 (3.8) | 1.92 (0.34–10.7) | 0.71 |
| Alcoholism | 7 (12.3) | 12 (11.3) | 1.21 (0.4–3.58) | 0.85 |
| Smoking habit | 10 (17.5) | 30 (28.3) | 0.22 (0.54–1.28) | 0.12 |
| APACHE IIa | 14 (10–16.5) | 10 (6–14) | <0.0001 | |
| SOFA (1)a,b | 3 (2–6) | 2 (1–4) | 0.003 | |
| Bacteraemia | 18 (31.6) | 14 (13.2) | 3.03 (1.28–7.22) | 0.005 |
| Genotype | ||||
| -308 TNF-α promoter polymorphism | 0.88 (0.33–2.37) | 0.77 | ||
| GG | 48 (84.2) | 91 (85.8) | ||
| GA/AA | 9 (15.8) | 15 (14.2) | ||
| TNF-β (NcoI polymorphism) | 1.25 (0.61–2.54) | 0.5 | ||
| GG/GA | 24 (42.1) | 39 (28.3) | ||
| AA | 33 (57.9) | 67 (63.2) | ||
| IL-10-1082 | 1.09 (0.46–2.61) | 0.8 | ||
| GG | 8 (14) | 15 (14.2) | ||
| GA/AA | 49 (86) | 91 (85.8) | ||
| Genotype -308 TNF GA/AA, TNF-β AA, IL-10-1082 GG | 1.48 (0.71–3.09) | 0.26 | ||
| Yes | 18 (31.5) | 43 (40.6) | ||
| No | 39 (68.5) | 63 (59.4) | ||
| Delayed AATa | 10 (6–25) | 5 (2.5–8) | <0.001 | |
Unless otherwise stated, values are expressed as n (%). aResults expressed as median (25th to 75th percentiles). bSOFA (1) means SOFA score of the first 24 hours in the hospital. AAT, appropriate antibiotic therapy; APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; RR, relative risk; SOFA, Sequential Organ Failure Assessment.