Table 2.
Studies of serum neuron-specific enolase to predict unfavorable outcome after cardiac arrest
| Reference | In-hospital CPR | NSE sampling time (hours) | Favorable outcome (n) | Unfavorable outcome (n) | Cut-off value (ng/ml) | Sensitivity (percentage) | Specificity (percentage) |
| [26] | No | 24 | 45 | 20 | >17 | 40 | 98 |
| [23] | Not specified | 24 | 27 | 35 | >20 | 51 | 89 |
| [12] | No | 72 | 18 | 25 | >33 | 65 | 100 |
| [24] | No | 72 | 28 | 24 | >16.4 | 70 | 100 |
| [25] | Yes/Noa | 48 | 34 | 76 | >25 | 59 | 100 |
| [13] | Yes/Nob | 72 | 28 | 69 | >65 | 50 | 96 |
| [27] | Yes/Noc | 24 | 51d | 356d | >33 | 44 | 100 |
| This study | Yes | 12–36 | 34 | 9 | >60 | 35 | 100 |
CPR = cardiopulmonary resuscitation; NSE = neuron-specific enolase. a77% out-of-hospital arrests; b56% were out-of-hospital arrests; c85% were out-of-hospital arrests; dNSE levels were determined in 231 of 407 patients.