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Times of appearance of clinical, biochemical, MRI, and x-ray findings suggesting HO
| Findings indicating HO | Clinical | ALP | MRI | X-rays |
| Time in days mean ± standard deviation | 18.7 ± 6.7 | 13.6 ± 4.7 | 20.2 ± 6.6 | 41.4 ± 8.2 |
Heterotopic ossification (HO) in the knee joint of 11 intensive care unit patients. Increase of serum levels of alkaline phosphatase (ALP) was the earliest indication of HO. MRI, magnetic resonance imaging.
