Table 3.
Biomarker levels pre-intubation and at two time points post-intubation
| Biological marker | Reference standard, mean (range) | Pre-intubation, median (range) | 0 to 8 hours post-intubation, median (range) | 12 to 26 hours post-intubation, median (range) | p valuea |
| IL-6 (pg/ml) | 43 (0 to 149) | 76 (3 to 652) | 132 (4 to 971) | 90 (3 to 550) | 0.34 |
| IL-8 (pg/ml) | 9 (1.2 to 16.7) | 235 (10 to 1,836) | 219 (10 to 2,115) | 68 (10 to 1,552) | 0.0003b |
| ICAM-1 (ng/ml) | 211 (115 to 306) | 631 (220 to 2,800) | 520 (198 to 3,970) | 492 (221 to 1,780) | 0.15 |
| vWF | % control | 368 (116 to 742) | 312 (40 to 814) | 359 (91 to 653) | 0.58 |
aRepeated measures analysis of variance comparing levels of cytokine at three different time points; bsee Figure 2. ICAM-1, intercellular adhesion molecule-1; IL, interleukin; vWF, von Willebrand factor.