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. 2005 Aug 1;146(4):487–497. doi: 10.1038/sj.bjp.0706363

Figure 4.

Figure 4

Effects of in vivo chronic application of NTG on ACh-induced increase in intracellular concentration of Ca2+ ([Ca2+]i) in AVECs. (A) Increase in [Ca2+]i in AVECs at 3 min after application of ACh (3 μM). The [Ca2+]i is expressed as the Fura-2 ratio (F340/F380). (a) Control rabbit; (b) NTG-treated rabbit. (B) Concentration-dependent effects of ACh on [Ca2+]i in AVECs (from rabbits with or without NTG treatment). Each concentration of ACh was intermittently applied for 3 min with a 10-min interval. The maximum response induced by ACh at a given concentration was plotted. Mean of data from five different preparations (from five different animals) with s.e.m.