Figure 3.

Dissection of the gross outward current into two components. (a) Concentration–response plot to XE991 at +20 mV for I_total, I_linear and I_out. I_linear can be defined as the instantaneously activated region and I_out as the slower activating component (see inset). Each point is the mean of 3–11 cells. IC₅₀ values were 5.8, 1.2 and 16.0 μM, respectively. (b) XE991-sensitive current recordings at +20 mV determined with different concentrations of XE991. Currents were evoked by 200 ms depolarisations from −60 to +20 mV. Concentrations used were 0.1 (bi), 10 (bii) and 300 μM (biii) XE991. (c) Bar chart illustrating XE991-sensitive current amplitudes of the I_total, I_linear and I_out components.