Figure 2.

Effects of D-sotalol on the MAPs recorded from the left ventricular muscle during the sinus rhythm. (a) Typical tracings of the surface lead II ECG and MAP signals during the sinus rhythm before (Control) and 5 min after 3.0 mg kg⁻¹ of D-sotalol injection. (b) Time courses of the effects of D-sotalol on the MAP duration at 90% repolarization level (MAP₉₀). The values of MAP₉₀(B), MAP₉₀(F), MAP₉₀(V) or MAP₉₀(M) were calculated using formula of Bazett, Fridericia, Van de Water or Matsunaga, respectively. Data are presented as mean±s.e.m. (n=6). The closed symbols represent the significant differences from each predrug control (C) value by P<0.05.