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Effect of a PAR4 antagonist on a general inflammatory reaction induced by carrageenan in the rat paw. Pepducin P4pal10 (0.5 mg kg−1)-dependent reduction of the carrageenan (200 μg)-mediated oedema formation (a) and granulocyte recruitment (b). Saline was used as a control for both the pepducin P4pal10 and carrageenan injections. Values are mean±s.e.m. of n=8 per group. *Significantly different from the vehicle+carrageenan group, P<0.05.
